Mesothelioma therapy guidelines

mesothelioma therapy guidelines

The most common treatment for mesothelioma involves a combination of surgery, chemotherapy and radiation therapy.

Supportive treatments can help relieve symptoms and improve quality of life for many mesothelioma patients.

The American Society of Clinical Oncology in 2018 published its updated mesothelioma treatment guidelines that doctors follow when treating patients diagnosed with mesothelioma.

mesothelioma therapy guidelines

Mesothelioma therapy guidelines

ASCO recommends the following common mesothelioma treatment options:


Clinical trials can also provide patients with emerging therapies.

These include immunotherapy, targeted therapy, and photodynamic therapy.

Type of mesothelioma, stage, cell type, and other factors decide the best treatment.

Treatments for Pleural Mesothelioma
Pleural mesothelioma affects the lining around a person’s lung. This lining is the pleura.

The best pleural mesothelioma treatments include:

Patients diagnosed in the early stages benefit most from surgery.

It offers them the best chance of living longer lives.

These procedures remove tumors from the chest area and improve the quality of life.

Extrapleural Pneumonectomy (EPP)

EPP removes the cancerous lung and all nearby areas where mesothelioma spreads.

This can include nearby lymph nodes, parts of the chest lining, heart lining and diaphragm.

Pleurectomy and Decortication (P/D)
P/D spares the lung and only removes cancerous parts of the pleural lining, the chest wall lining, and the diaphragm. This is a less aggressive surgery.


Doctors may recommend chemotherapy to patients who are not eligible for surgery.

This mesothelioma treatment also helps extend survival rates.

A 2016 Wayne State University study found patients given a combination of chemo drugs lived three times longer than patients without it.

Hyperthermic intrathoracic chemotherapy

(HITHOC): An experimental procedure that delivers heated chemotherapy drugs throughout the chest cavity.


Radiation therapy controls symptoms when surgery is not an option.

It eases symptoms such as chest pain and discomfort.

And it can also reduce the risk of local recurrence when combined with surgery.

External Beam Radiation Therapy: Machine placed outside the body delivers X-ray beams to kill cancer cells

Brachytherapy: Uses a radioactive implant to kill nearby cancer cells

Hyperthermic intrathoracic chemotherapy may help pleural mesothelioma patients, too.

It delivers a heated chemo drug treatment to the chest cavity after surgery.

Mesothelioma doctors are testing and improving this procedure.

What Is Multimodal Therapy?

Multimodal therapy combines two or more conventional treatments. Another name for this therapy is multimodality treatment.

The 2018 ASCO mesothelioma guidelines show multimodal therapies resulted in overall survival of 13 to 23.9 months.

Understanding Palliative Care for Mesothelioma
Palliative treatment is also known as supportive care.

It can improve quality of life and relieve symptoms from cancer and its therapies.

Common palliative procedures for mesothelioma include:

Thoracentesis: Removes fluid buildup around the lungs.
Pleurodesis: Eliminates space where fluid can develop.

Radiation: Can shrink tumors to reduce chest pain.

This is for peritoneal patients. It removes fluid buildup from the abdominal area.

Pericardiocentesis: Doctors use this for pericardial mesothelioma patients.

It removes fluid that collects in the sac surrounding the heart.

A 2016 study in Current Medical Research and Opinion shows earlier palliative care lessens pain at all mesothelioma stages.

What Are the Emerging Treatments for Mesothelioma?

New mesothelioma treatment options in development include immunotherapy and photodynamic therapy.

Researchers are testing these in clinical trials to ensure safety and efficacy.

At some point, these experimental treatments could become conventional treatments.

Clinical Trials

Clinical trials are medical studies. They involve patients who take experimental treatments or a combination of new procedures.

The goal is to find a cure or improve life expectancy. Doctors and researchers track these studies.

Mesothelioma patients are eligible for clinical trials. Some of these studies are free.

Researchers are recruiting patients for these clinical trials:

Olaparib for Malignant Mesothelioma: Researchers will investigate if the drug olaparib can cause shrink tumors in people with certain gene mutations.

Combining LMB-100 with SEL-110:

The drug LMB-100 kills mesothelioma tumors. But antibodies reduce its effectiveness.

Researchers will add the drug SEL-110 to see if it prevents antibodies from forming.

Pembrolizumab for Advanced Pleural

Mesothelioma: Researchers will examine the side effects of pembrolizumab and if it can outperform the standard chemo drugs.

Mesothelioma therapy guidelines

Treatments for Peritoneal Mesothelioma

Peritoneal mesothelioma forms on the tissue lining the abdomen. This lining is also known as the peritoneum.

The best peritoneal mesothelioma treatments include:

Heated Intraperitoneal Chemotherapy (HIPEC):

This is the most effective mesothelioma treatment option for this type of cancer.

Doctors deliver heated chemotherapy drugs into the abdominal cavity after surgery. The process kills remaining cancer cells.

Cytoreductive Surgery:

Removes cancerous growths from the lining of the abdomen. HIPEC often follows this treatment.

Conventional mesothelioma treatments, including radiation, may also help peritoneal mesothelioma patients.

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mesothelioma therapy guidelines

Randhir Deswal

Hi, I am Randhir Singh a Solo Travel Blogger form Rohtak Haryana. I am a writer of Lyrics and Quotes.

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